Hello,everyone!

I want to assess the significance of Fold-change using t-test. Normally, if I know the data of case and control, I can perform the t-test, but the problem is that I only have the log2 fold change ,so I don't know how to performing the t-test only by calculated values of fold-change. Is it possible?

I am new to this field, please help. Thank you very much!

Do you have the SE of the fold-change? You can't calculate the p-value from only a fold-change, you'll need some other value to let you know how confident that estimate is.

To the best of my knowledge, this is not possible with just the fold change.